The natural CRISPR locus of a bacteria host encodes multiple guide RNAs (gRNAs) on a single array to target the genome of the invading phage pathogen. Over the past decade, CRISPR tools have leveraged such host-defense mechanisms to enable multiplex gene editing in a variety of cells and organisms. However, lengthy genetic payloads and insufficient transcription on the array have limited the scalability and efficiency of multiplex gene editing. Moreover, existing multiplex strategies have been facing difficulties in pairing with base editing and prime editing approaches. Recently, Xue Sherry Gao’s lab at Rice University has developed DAP arrays for efficient multiplex base editing (MBE) and multiplex prime editing (MPE) with only minimal payloads.