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Summer SciComm Series: Cognitive Load

[ad_1] We are now at the second post in our Summer SciComm series and it’s time for one of my favorite scicomm bandstands: cognitive load.  Cognitive load The Wikipedia definition of cognitive load states: “cognitive load refers to the used amount of working memory resources. There are three types of cognitive load: intrinsic cognitive load …

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Using CRISPR/Cas9 to Edit Disease Out of the Genome

[ad_1] This post was originally written in 2014 by Kendall Morgan and updated in 2022 by Lucie Wilson. Lucie is an Addgene co-op from Northeastern University.  There can be no doubt that CRISPR/Cas9 technology has been a breakthrough for the genome-editing field. It has the possibility to treat human genetic diseases, and several treatments are …

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DAP arrays for multiplex gene editing

[ad_1] The natural CRISPR locus of a bacteria host encodes multiple guide RNAs (gRNAs) on a single array to target the genome of the invading phage pathogen. Over the past decade, CRISPR tools have leveraged such host-defense mechanisms to enable multiplex gene editing in a variety of cells and organisms. However, lengthy genetic payloads and …

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Bioinformatics at Addgene

[ad_1] From the beginning, one of Addgene’s goals was to ensure the scientific community obtained high-quality data for our DNA-based reagents. Not only do we extract as much information as possible from depositing laboratories and associated publications, but our quality control (QC) standards have evolved over the years to keep up with the latest tools. …

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Corralling and Cornering the Goldilocks Antibody

[ad_1] Have you ever been stuck googling about an antibody that will be essential to your new research project, but unsure which one will mark your target the best, or even which one will work for your application? Like many scientists, I have spent hours sifting through comments and papers to find the most reliable …

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